The DNA-To-Be inside the Chromosome-To-Be Detaches Itself from the Core
The illustration on the left attempts to explain the time-to-time development of the DNA-to-be during its evolutionary journey, encountering events resembling those of the present day metaphase.
A re-examination of the process by which the core splits up, whereby all the compounds inside it are dismantled and divided, tells us that there are two sets of forces working on the core: one doing everything it can to divide the core; the other trying as hard as possible to keep it intact.
As is shown in 1a, the lower part is here envisioned to be the core that wishes to dismantle the compounds, which in this case represent DNAs-to-be (depicted as two plates, envisioned to represent sugar phosphate compounds). Following its division, each of the split-up parts of the core will—in a process resembling that of anabolism—work its way towards total recovery. Through the various external substances and with the aid of the rays of the sunlight, each part will then completely regain the pre-division condition of the core intact.
Now, look at illustrations 2a, 2b, and 2c which, though what is depicted in them closely resembles the composition of DNA, convey the same meaning as is represented by illustration 1. It is necessary to explain here that during the first division that occurred naturally, the DNA-to-be divided itself into two such that each cell-to-be got half of the DNA-to-be.
After each cell-to-be begins to develop, the DNA-to-be is again replicated, chemically this time, and becomes double-stranded again. In the divisions that follow, the process always occurs chemically. Here the division is preceded by the “unzipping” of the DNA-to-be, instantly after which the DNA-to-be replicates. It could be said that at this phase the division and the replication of the DNA-to-be occur almost simultaneously.
At the upper part, while the compounds dismantle themselves, the DNA twists. This naturally pose a great shock to the compounds. The phrase “great shock” is here used for the reason that the speed at which this change occurs is extremely greater than that at which the evolutionary change takes place at the other parts of its bodily mecahnisms.
We refer to it as DNA-to-be, because it was then still inside the bag of the Chromosome-to-be which itself had not had any obvious form yet.
As we know, quite a number of single-Celled living creatures divides themselves; in fact, some of them do so every twenty minutes. This is certainly too high a frequency as their division lasts only a very short period of time. It is quite likely that in the Cell-to-be the intervals had not been that short, particularly because it had then not secured its present form yet. However, as conditions then were conducive enough to create such shock, the detachment of DNA-to-be from its hold was just inevitable.
On the left hand side of this page is an illustration of the time-to-time evolutionary development of DNA-to-be when, even within only one period of its 360-degree twist, it is apt to divide itself millions of times. In illustration 3 the DNA-to-be is seen to be in such a condition where its upper end is connected to the outer skin and its lower end connected to the core. The core having split off, the DNA-to-be not only divides but is also disconnected from the upper end and the core itself. This is further assured by the fact that as the DNA-to-be twists, it becomes shorter. Apart from detaching itself bit-by-bit from the core, it also detaches from its original position at the upper part. The way the lower part detaches itself is quite unlike the way the upper part does, because at the lower part the bond between the core and the DNA-to-be is stronger than the bond between the DNA-to-be and its surroundings. The bond being stronger at the lower part, there apparently still exists in both the core and the lower end of the DNA-to-be a sort of a connector resembling thread-like slime.
In illustration 4, the gray line indicates that the centre and the lower part of the DNA-to-be are still connected. The DNA-to-be, affected by the division of the twisting Cell-to-be, not only gets twisted but also twists—though slowly yet surely—by itself.
Illustration 5 shows the DNA-to-be continuously twisting, by which the gray line (then still holding the end of the DNA-to-be) is pulled, eventually causing it to elongate. These endless twists cause the “thin line” (let’s just call it the Microtubule-to-be) to become tense to the extent that its hold is dragged toward the middle of the DNA-to-be (see arrow in illustration 6).
Soon after the line reaches a particular location at the body of the DNA-to-be—to be precise, at the location where the defect exists—it stops. There are a number of possibilities concerning the Microtubule’s-to-be getting itself caught (or its stoppage) at that point. Natural events could also serve as a possibility. The explanation to this is that at the time the division occurs, tensions of maximum degrees are in such abundance in the area that there emerge “peculiarities”, e.g. cleavages and mounds on which the end of the Microtubule-to-be may get itself caught. It is also possible that at that very location, and soon after the arrival of the tip (end) of the Microtubule-to-be, peculiarities of significance begin to show themselves up in the compounds, which then leads to the accumulation of the compounds at the tip (end), thereby causing it to be bonded. Let’s just refer to this location as the centromere-to-be.
It is perhaps necessary to add here that illustrations 3, 4, 5, and 6 are but portrayals of what is happening from time to time during its evolution, which is very similar to what’s happening during the prophase. Obviously, the change is by no means one that takes place within a very short period of time.
Triggered by the twists of both parts of the Cell-to-be during their division, which further causes the DNA-to-be to twist, in its evolution therefore the Microtubule-to-be that holds the DNA-to-be gets twisted too.
As the twist continues, the DNA-to-be turns shorter. The Cell-to-be has now enough room to hold 1,262 Chromosomes just as it is in the Ophioglossum. In illustration 7, the twists of the DNA-to-be are represented by the red spots inside the green ovals.
Apart from the movement itself, which is natural to such division, there also occurs a change in the location of the DNA-to-be inside those parts of the Cell-to-be which were taken along during the division that occurred in the metaphase.
The change elaborated in the explanations and illustrations above could be referred to as the gradual change in DNA-to-be inside the Chromosome-to-be during the metaphase.
It is necessary to add here that with the DNA-to-be constantly changing, moving, and evolving, the Microtubule-to-be finds it hard to keep up pace with it and to break itself loose from its hold at certain phases. All it is able to do is to let itself stay hooked to its hold throughout the Metaphase and the Anaphase.
It needs to be understood here that though in reality the DNA-to-be is known to be flexible and soft like wet noodles, in the illustrations, however, it is intentionally made to appear straight and stiff only for the purpose of facilitating explanations.